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DIAN Part 3: Genetic and Data Protection for Volunteers
18 November 2008. DIAN asks a lot of its study volunteers...
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DIAN Part 2: The Science, Inner Workings of the Network
17 November 2008. Scientifically, the Dominantly Inherited Alzheimer Network (DIAN) will test three hypotheses...
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LOAD Genetics Study Is All in the Families
14 November 2008. An analysis of genetic ties to late-onset Alzheimer disease (LOAD) is news not so much for its actual results, but instead for the potential it represents...
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News Brief: Controversial ApoE Testing Ends for Now
14 November 2008. A firm that offered ApoE genotyping to consumers online under the product name Alzheimer’s Mirror has shut down...
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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DIAN: International Network to Chart AD Preclinical Decade
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The rarest kind of Alzheimer disease, the form that is inherited from parent to child with a cruel 50 percent likelihood, has long been marked by its untapped opportunities. Affected families have made possible both the discovery of the first three Alzheimer’s genes and the elaboration of the amyloid hypothesis. Beyond that, these families have much more to give to research, and gain from it, because the preclinical phase of AD can be studied and targeted for prevention in still-healthy carriers who are certain to develop AD in the future. This has been difficult to do because these families are rare and live all across the globe. Now, an international registry called Dominantly Inherited Alzheimer’s Network (DIAN) is preparing to fill the gap. Starting in January 2009, this 10-center, publicly funded consortium will open its doors for adult children of eFAD families. Carriers, non-carriers, and those who do not want to know their genetic status are welcome to join a comprehensive study that aims to pave the way for future prevention trials.
 DIAN: Registry for eFAD to Chart Alzheimer’s Preclinical Decade
DIAN Part 2: The Science, Inner Workings of the Network
DIAN Part 3: Genetic and Data Protection for Volunteers |
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Participate in Alzforum Survey on Early Detection of AD
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Please participate in a quick survey designed to gauge your perceptions and knowledge of early detection of Alzheimer disease. The survey was created by Alzforum editors and the leadership of the Geoffrey Beene Foundation Alzheimer's Initiative as follow-up to Alzforum's Virtual Town Hall Meeting on June 30, 2008. The Beene Foundation sponsored the Virtual Town Hall meeting to complement the efforts of the Alzheimer's Study Group (ASG), an independent working group mandated by the United States Congress to develop a national strategic plan for Alzheimer disease. Please select the appropriate survey link below. Thank you for your participation.
If you are an Alzheimer Researcher, click here.
If you are a member of the General Public, click here.
View Researcher Survey Results; View Public Survey Results
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What's New
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Comments - Posted 19 November 2008
Read remarks by Bart De Strooper about "Are you in favor of ICAD going annual?" |
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Conferences - Posted 18 November 2008
WFN XVIII World Congress on Parkinson’s Disease and Related Disorders: 13-16 December 2009, Miami Beach, FL, U.S.A. |
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Comments - Posted 18 November 2008
Read remarks by Gerd Multhaup about Hung LW et al.
PAPER: Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. |
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Comments - Posted 18 November 2008
Read remarks by Yaakov Stern about Roe CM et al.
PAPER: Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. |
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Comments - Posted 18 November 2008
Read remarks by William Polsky about
Green KN et al.
NEWS: Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau |
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Comments - Posted 18 November 2008
Read remarks by Jungsu Kim about Ding Y et al.
PAPER: Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. |
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Comments - Posted 18 November 2008
Read remarks by Lon Schneider about Zhao X et al.
PAPER: Tarenflurbil Protection from Cytotoxicity is Associated with an Upregulation of Neurotrophins. |
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Desperately Seeking Antibodies - Posted 18 November 2008
A request for some Alz-50 or MC1 antibody. "I am just finishing my PhD and would love to look at confirmational changes in relationship to other AD pathology in human tissue."
A question about the amyloid-beta antibody 4G8, from Rufus Akinyemi: How specific is 4G8 for insoluble amyloid fibrils in amyloid plaques? I'm getting significant intracellular IR (suggesting intracellular amyloid presence) while using 4G8 to stain f! or extracellular amyloid. |
SEE MORE |
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